I had the treatment of group B of these women. Looks like I might be lucky….That said, trial was for regular breast cancer, early diagnosis and I was late and this was not trialled for my rarer form of inflammatory breast cancer
However….The Texas Programme for Inflammatory Breast Cancer issued this (rather lengthy) statement, which I have shortened.
Those of you who are active on social media may have noticed that this week, Genentech announced that their ongoing phase 3 trial of Pertuzumab (Perjeta) along with Trastuzumab (Herceptin) and chemotherapy has reached its primary endpoint (https://www.gene.com/…/phase-iii-aphinity-study-shows-genen…). The press release notes that the results would be shared at a major medical conference this year. We’d like to proactively answer some questions about the impact of these results on IBC care with this post.
Patient population: Early breast cancer patients (IBC excluded) with HER2+ tumors, removed by surgery and who are candidates for adjuvant chemotherapy with a Trastuzumab-containing regimen.
Study arms: Physicians choice of 3 acceptable standard types of chemotherapy along with Trastuzumab for everyone for 6-8 cycles, followed by Trastuzumab to complete 1 year. 50% of patients received Pertuzumab in addition to this for the whole year and the rest received a placebo.
Take-home for IBC patients: All we know from the press-release so far is that the result is positive, but we don’t know the details. These data have only a limited impact on how we approach IBC care due to the fact that the current standard of care for IBC is neoadjuvant (pre-surgical) chemotherapy. The FDA approval label for Pertuzumab specifically includes IBC and we routinely use Pertuzumab for our HER2+ IBC patients.
Inflammatory breast cancer is treated with neoadjuvant chemotherapy – chemo first, surgery/radiotherapy afterwards….
So…perhaps, perhaps, perhaps (do click to hear Doris!)
I have detached my 5 day ECG and returned it (as instructed) to an empty Reception area. I will have to assume that it will be picked up, read and reported on. Meantime I am left with the mark of Zorro on my chest. Another procedure, another memento.
I await the next round of prodding and poking, but have a hospital-free week (at present), which I am filling/have filled with a selection of birthday treats. Given I rose from my bed and survived an over-long blue lip experience, two things (of the shallow variety) sprang to mind.
- that every birthday should be a “big” birthday
- that lips should always be red (Viva la Diva red today!)
I have been made-over by a wonderful lady-boy, acquired crimson talons on my fingers , cockail-ed and dined, shopped until I dropped (and even used an uber cab – not my app, not my idea but I am happy to hang on to hipper coat-tails than mine). The next highlight is to singalong with Calamity Jane (Doris Day & Howard Keel).
This may not exactly suggest a range of activities that includes something for everyone but I care, not a jot…I can place my cowgirl neckerchief over my tender spot and get back to those black Dakota hills…
Calamity Jane teaser
Try to imagine housework being done in the style of – a mix of Cher in Mermaids and Mickey Mouse in The Sorcerer’s Apprentice – and you have me this morning…mopping the floors to Tell Him….
Whilst I really don’t want to be thinking about HIS kiss…and where he was/is planting it – just too sordid, it was an hour or so’s light relief. It gave the cats (and me) an excuse for some exercise – theirs (suffice it to say) involved tearing out of the house at top whack. And the bonus is..I now have very well polished wooden floors and a sparkly house.
So, I am “ready” for next stage of medical intervention. Monday kicks off with a “new” nurse visiting to treat me. Will she be chatty? Will I want to chat? What will be her particular “observation” style? Will I be able to read my book? Will I be here? (I do often ponder going AWOL). And in my current mindset, I feel I should probably launch into a rendition of Que Sera Sera.!
My inner arm is already extensively bruised (from elbow to wrist) in charming shades of purple and yellow (not quite the 50 shades of grey!) resulting from 6 vials of blood tests the other day (6? I know…seems excessive and I have no idea why so many and have got past bothering to ask!). Then Tuesday is back to see oncology consultant…I have not had scans recently so I don’t expect there will be anything to report other than booking my next gamut of tests, so I don’t go with too heavy a heart this time. I suspect that I may be rather tempting fate but surely (surely…) it must be someone else’s turn for the wicked fairy.